Arizona CardinalsARIARIAway

Arizona Cardinals at San Francisco 49ers

Sunday, September 27, 2026 · 4:05 PM ET

Levi's Stadium · Santa Clara, CA

FOXOutdoor

Kickoff in 9 days

San Francisco 49ersSFSFHome

Game-week context

ARIAway
Rest
7 days
Travel
608 mi
SFHome
Rest
7 days
Travel
0 mi

Market lines

via DraftKings · 14h ago

Spread

SF -8.5

-110 / -110

Total

47.5

O -110 / U -110

Moneyline

ARI +370 / SF -485

Weather at kickoff

Open-Meteo · 13h ago

Clear

80°F

Wind

5 mph

from NW

Precip chance

1%

Humidity

27%

Schedule context · Week 3

ARI
  1. Wk 1@LACSundaySep 13
  2. Wk 2vsSEASundaySep 20
  3. Wk 3@SFSundaySep 27
  4. Wk 4@NYGSundayOct 4
  5. Wk 5vsDETSundayOct 11
SF
  1. Wk 1@LAThursdaySep 10
  2. Wk 2vsMIASundaySep 20
  3. Wk 3vsARISundaySep 27
  4. Wk 4vsDENSundayOct 4
  5. Wk 5@SEASundayOct 11

Updates closer to kickoff

Injuries

Status reports populate during game week.